Modulation of medial geniculate nucleus neuronal activity by electrical stimulation of the nucleus accumbens

Publication date: 12 November 2015 Source:Neuroscience, Volume 308 Author(s): K.M. Barry, A.G. Paolini, D. Robertson, W.H.A.M. Mulders Dysfunctional sensory gating has been proposed to result in the generation of phantom perceptions. In agreement, it has been recently suggested that tinnitus, a phantom perception of sound commonly associated with hearing loss, is the result of a breakdown of circuitry involving the limbic system and the medial geniculate nucleus (MGN) of the thalamus. In humans with tinnitus, structural changes and abnormal activity have been found to occur in the auditory pathway as well as parts of the limbic system such as the nucleus accumbens (NAc). However, at present, no studies have been conducted on the influence of the NAc on the MGN. We investigated the fu…

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