Frontostriatal Gating of Tinnitus and Chronic Pain

Publication date: October 2015 Source:Trends in Cognitive Sciences, Volume 19, Issue 10 Author(s): Josef P. Rauschecker, Elisabeth S. May, Audrey Maudoux, Markus Ploner Tinnitus and chronic pain are sensory–perceptual disorders associated with negative affect and high impact on well-being and behavior. It is now becoming increasingly clear that higher cognitive and affective brain systems are centrally involved in the pathology of both disorders. We propose that the ventromedial prefrontal cortex and the nucleus accumbens are part of a central ‘gatekeeping’ system in both sensory modalities, a system which evaluates the relevance and affective value of sensory stimuli and controls information flow via descending pathways. If this frontostriatal system is compromised, long-lasti…

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