Chronic mountain sickness (CMS) results from chronic hypoxia. It is unclear why certain highlanders develop CMS. We hypothesized modest increases in fetal hemoglobin (HbF) is associated with lower CMS severity. In this cross-sectional study, we showed that normal HbF levels (median 0.4%) were found in all 153 adult Andean natives in Cerro de Pasco, Peru. Compared to healthy adults, the borderline elevated hemoglobin group frequently had symptoms (headaches, tinnitus, cyanosis, dilatation of veins) of CMS. (Source: Experimental Hematology)
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