Wednesday, January 13, 2016

Sodium salicylate reduces the level of GABAB receptors in the rat’s inferior colliculus

Publication date: 1 March 2016 Source:Neuroscience, Volume 316 Author(s): S. Butt, F. Ashraf, L.A. Porter, H. Zhang Previous studies have indicated that sodium salicylate (SS) can cause hearing abnormalities through affecting the central auditory system. In order to understand central effects of the drug, we examined how a single intraperitoneal injection of the drug changed the level of subunits of the type-B γ-aminobutyric acid receptor (GABAB receptor) in the rat’s inferior colliculus (IC). Immunohistochemical and western blotting experiments were conducted three hours following a drug injection, as previous studies indicated that a tinnitus-like behavior could be reliably induced in rats within this time period. Results revealed that both subunits of the receptor, GABABR1 and …

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