Altered vesicular glutamate transporter distributions in the mouse cochlear nucleus following cochlear insult

Publication date: 19 February 2016 Source:Neuroscience, Volume 315 Author(s): A.N. Heeringa, R.A. Stefanescu, Y. Raphael, S.E. Shore Vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) have distinct distributions in the cochlear nucleus that correspond to sources of the labeled terminals. VGLUT1 is mainly associated with terminals of auditory nerve fibers, whereas VGLUT2 is mainly associated with glutamatergic terminals deriving from other sources that project to the cochlear nucleus (CN), including somatosensory and vestibular terminals. Previous studies in guinea pig have shown that cochlear damage results in a decrease of VGLUT1-labeled puncta and an increase in VGLUT2-labeled puncta. This indicates cross-modal compensation that is of potential importance in somatic tinni…

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