Authors: Monzani D, Genovese E, Pini LA, DI Berardino F, Alicandri Ciufelli M, Galeazzi GM, Presutti L Abstract As L-type voltage-gated calcium channels (VGCCs) control Ca(2+) influx and depolarisation of cardiac and vascular smooth muscle, they represent a specific therapeutic target for calcium channel blockers (CCBs), which are approved and widely used to treat hypertension, myocardial ischaemia and arrhythmias. L-type currents also play a role in calcium entry in the sensory cells of the inner ear. In hair cells of both cochlea and labyrinth, calcium cytoplasmic influx is the first physiological process that activates complex intracellular enzymatic reactions resulting in neurotransmitter release. Excessive calcium ion entry into sensory cells, as a consequence of L-VGCCs malfu…
from Tinnitus Miracle Book http://ift.tt/1IAQSpf via check my site
from Tumblr http://ift.tt/1PejitG
No comments:
Post a Comment