Spatial Masking: Development and Testing of a New Tinnitus Assistive Technology.

CONCLUSIONS: This study indicates that spatial masking of tinnitus is feasible, of benefit to many participants, and warrants further trials. PMID: 26817495 [PubMed - as supplied by publisher] (Source: Assistive Technology)

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Which tinnitus-related characteristics affect current health-related quality of life and depression? A cross-sectional cohort study

Tinnitus is sometimes associated with lower health-related quality of life (HRQoL) and depressive symptoms. However, only limited evidence exists identifying which tinnitus characteristics are responsible for these associations. The aim of this cross-sectional study was to assess associations between tinnitus, HRQoL, depressive symptoms, subjective tinnitus loudness and audiometrically assessed tinnitus characteristics (e.g., hearing threshold). Two hundred and eight outpatients reporting tinnitus completed questionnaires on tinnitus (Tinnitus Handicap Inventory, THI), HRQoL (World-Health-Organisation Quality of Life Short Form Survey, WHOQOL-BREF), and depressive symptoms (Beck Depression Inventory, BDI), and underwent audiometry. (Source: Psychiatry Research)

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Long‐Term Distributed Repetitive Transcranial Magnetic Stimulation for Tinnitus: A Feasibility Study

ConclusionsOur study demonstrated that rTMS can be delivered in a distributed schedule that is well‐tolerated, feasible and may prove to be clinically beneficial. A long‐term distributed rTMS schedule for tinnitus may warrant investigation as an alternative to the short‐term aggregated treatment schedules more frequently used previously. For the many varied therapeutic uses of rTMS (established and investigational), treatment schedules are relatively unexplored, and deserve further attention. (Source: Neuromodulation: Technology at the Neural Interface)

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Hearing difficulty and tinnitus among U.S. workers and non‐workers in 2007

ConclusionsHearing difficulty and tinnitus are prevalent in the U.S.; especially among noise‐exposed workers. Improved strategies for hearing conservation or better implementation are needed. Am. J. Ind. Med. Published 2016. This article is a U.S. Government work and is in the public domain in the USA (Source: American Journal of Industrial Medicine)

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Protective effects of the seaweed phlorotannin polyphenolic compound dieckol on gentamicin-induced damage in auditory hair cells

This study investigated the protective effects of dieckol on drug-induced ototoxicity in cochlear cultures obtained from neonatal mice. (Source: International Journal of Pediatric Otorhinolaryngology)

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Altered top-down cognitive control and auditory processing in tinnitus: evidences from auditory and visual spatial stroop.

CONCLUSIONS: Tinnitus is associated both with modality-specific deficits along the auditory processing system and an impairment of cognitive control mechanisms that are involved both in vision and audition (i.e. that are supra-modal). We postulate that this deficit in the top-down cognitive control is a key-factor in the development and maintenance of tinnitus and may also explain some of the cognitive difficulties reported by tinnitus sufferers. PMID: 25420904 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)

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Diagnostic criteria for Menière's disease.

Authors: Lopez-Escamez JA, Carey J, Chung WH, Goebel JA, Magnusson M, Mandalà M, Newman-Toker DE, Strupp M, Suzuki M, Trabalzini F, Bisdorff A Abstract This paper presents diagnostic criteria for Menière’s disease jointly formulated by the Classification Committee of the Bárány Society, The Japan Society for Equilibrium Research, the European Academy of Otology and Neurotology (EAONO), the Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) and the Korean Balance Society. The classification includes two categories: definite Menière’s disease and probable Menière’s disease. The diagnosis of definite Menière’s disease is based on clinical criteria and requires the observation of an episodic vertigo syndrome associated with low- to me…

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Attentional Bias in Patients with Decompensated Tinnitus: Prima Facie Evidence from Event-Related Potentials

In this study, we adopted an objective indicator of attentional processing, i.e. the mismatch negativity (MMN), to assess the attentional bias in patients with decompensated tinnitus. Three kinds of pure tones, D1 (8,000 Hz), S (8,500 Hz) and D2 (9,000 Hz), were used to induce event-related potentials (ERPs) in the normal ear. Employing the oddball paradigm, the task was divided into two blocks in which D1 and D2 were set as deviation stimuli, respectively. Only D2 induced a significant MMN in the tinnitus group, while neither D1 nor D2 was able to induce MMN in the control group. In addition, the ERPs in the left hemisphere, which were recorded within the time window of 90-150 ms (ERP90-150 ms), were significantly higher than those in the right hemisphere in the tinnitus group, while no s…

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Hearing complaints of workers in a pottery industry of the city of João Pessoa/PB

Conclusion: the results of this study show a direct association between time of exposure to noise and auditory symptoms, which suggests that better hearing health education politics may be necessary. In addition, it was found that workers knew the risks of noise on health, but did not comprehend that the auditory symptoms they have may be associated with this important physical risk, which can hinder actions to prevent noise hazards. (Source: Revista CEFAC)

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Ultrasound exposure could be making people ill, study finds

University of Southampton research finds public places can feature high frequency sounds beyond occupational health limitsExposure to high frequency sounds beyond the range of human hearing from public address systems, loudspeakers and door sensors in public places could be making people feel ill, research suggests.Increasing exposure to ultrasound in the air was recorded in railway stations, museums, libraries, schools and sports stadiums in which it is claimed people have complained of nausea, dizziness, migraine, fatigue and tinnitus. Continue reading… (Source: Guardian Unlimited Science)

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Surgical management of vestibular schwannomas after failed radiation treatment

Abstract Increasing numbers of patients with vestibular schwannoma (VS) have been treated with focused-beam stereotactic radiation treatment (SRT) including Gamma knife, CyberKnife, X-knife, Novalis, or proton beam therapy. The purpose of this study was to document the incidence of tumor regrowth or symptoms that worsened or first developed following SRT and to discuss surgical strategies for patients who have failed SRT for VS. A consecutive series of 39 patients with SRT failed VS were surgically treated. Clinical symptoms, tumor regrowth at follow-up, intraoperative findings, and surgical outcome were evaluated. There were 15 males and 24 females with a mean age of 51.8 years. Thirty-six patients (92.3 %) demonstrated steady tumor growth after SRT. Two (5.1 %) patients with …

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Genetic risk factors of cisplatin induced ototoxicity in adult patients.

The objective of this prospective study was to investigate a possible genetic background to this variability. We assessed ototoxicity induced by therapeutic doses of CDDP in adult patients with germinative testicular tumors, or other tumors treated with an identical CDDP dosage scheme. Audiological examination before, during and after the treatment has shown deterioration in hearing; first in the high-frequencies and with increased CDDP cumulative doses, impairment in other frequencies as well. Occurrence of tinnitus was not dependent on the administered dose of CDDP, or the other risk factors examined in this study. The association of CDDP induced ototoxicity with genetic polymorphisms in candidate genes was examined. Our study has demonstrated an association of early onset of CDDP induc…

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Effects of Intralabyrinthine Hemorrhage on the Cochlear Elements: A Human Temporal Bone Study

Conclusion: These findings suggest that such patients could be good candidates for hearing aid or cochlear implant if they have profound sensorineural hearing loss. (Source: Otology and Neurotology)

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Disability evaluation in acoustic blast trauma

Conclusion: Objective hearing tests should be carried out after one year or more before evaluation of permanent disability. (Source: Indian Journal of Occupational and Environmental Medicine)

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Postoperative Imaging Findings following Sigmoid Sinus Wall Reconstruction for Pulse Synchronous Tinnitus [HEAD & NECK]

CONCLUSIONS: The imaging findings following sigmoid sinus wall repair are characteristic. Graft materials may result in extrinsic compression of the sigmoid sinus, and this finding may be confused with dural venous thrombosis. Awareness of the imaging characteristics of the graft materials used enables this differentiation. (Source: American Journal of Neuroradiology)

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Sodium salicylate reduces the level of GABAB receptors in the rat’s inferior colliculus

Publication date: 1 March 2016 Source:Neuroscience, Volume 316 Author(s): S. Butt, F. Ashraf, L.A. Porter, H. Zhang Previous studies have indicated that sodium salicylate (SS) can cause hearing abnormalities through affecting the central auditory system. In order to understand central effects of the drug, we examined how a single intraperitoneal injection of the drug changed the level of subunits of the type-B γ-aminobutyric acid receptor (GABAB receptor) in the rat’s inferior colliculus (IC). Immunohistochemical and western blotting experiments were conducted three hours following a drug injection, as previous studies indicated that a tinnitus-like behavior could be reliably induced in rats within this time period. Results revealed that both subunits of the receptor, GABABR1 and …

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Altered vesicular glutamate transporter distributions in the mouse cochlear nucleus following cochlear insult

Publication date: 19 February 2016 Source:Neuroscience, Volume 315 Author(s): A.N. Heeringa, R.A. Stefanescu, Y. Raphael, S.E. Shore Vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) have distinct distributions in the cochlear nucleus that correspond to sources of the labeled terminals. VGLUT1 is mainly associated with terminals of auditory nerve fibers, whereas VGLUT2 is mainly associated with glutamatergic terminals deriving from other sources that project to the cochlear nucleus (CN), including somatosensory and vestibular terminals. Previous studies in guinea pig have shown that cochlear damage results in a decrease of VGLUT1-labeled puncta and an increase in VGLUT2-labeled puncta. This indicates cross-modal compensation that is of potential importance in somatic tinni…

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Visual snow: A thalamocortical dysrhythmia of the visual pathway?

Publication date: Available online 11 January 2016 Source:Journal of Clinical Neuroscience Author(s): Jenny L. Lauschke, Gordon T. Plant, Clare L. Fraser In this paper we review the visual snow (VS) characteristics of a case cohort of 32 patients. History of symptoms and associated co-morbidities, ophthalmic examination, previous investigations and the results of intuitive colourimetry were collected and reviewed. VS symptoms follow a stereotypical description and are strongly associated with palinopsia, migraine and tinnitus, but also tremor. The condition is a chronic one and often results in misdiagnosis with psychiatric disorders or malingering. Colour filters, particularly in the yellow-blue colour spectrum, subjectively reduced symptoms of VS. There is neurobiological evidence f…

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Malignant Jugular Paraganglioma: Unusual Presentation on 68Ga DOTANOC PET/CT

We report a 40-year-old woman of jugular paraganglioma, presenting with right-sided neck swelling, hearing loss, and pulsatile tinnitus. Contrast-enhanced CT temporal bone revealed a mass in the right jugular foramina and extending inferiorly to internal jugular vein. 68Ga DOTANOC PET/CT was performed, which revealed somatostatin receptor expressing lesion in the right internal jugular vein and extension into sigmoid sinus and additional metastatic focus in the sacrum. (Source: Clinical Nuclear Medicine)

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Tinnitus and its current treatment–Still an enigma in medicine

Publication date: Available online 30 December 2015 Source:Journal of the Formosan Medical Association Author(s): Santosh Kumar Swain, Saumyadarshan Nayak, Jayprakash Russel Ravan, Mahesh Chandra Sahu Tinnitus is a phantom auditory perception that occurs in humans. Tinnitus, which is a distressing problem affecting many people around the world, is commonly referred to as ringing in the ears. No effective drug therapy is available for this elusive disease, although much research work into mechanism and possible treatment is underway. As yet, there are no Food and Drug Administration approved drugs available and the quest for a new treatment option for tinnitus focus on important challenges in tinnitus management. A number of options have been used to treat patients with tinnitus, but …

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Comparison of nerve combing and percutaneous radiofrequency thermocoagulation in the treatment for idiopathic trigeminal neuralgia

Conclusion Nerve combing and RF are both satisfactory treatment strategies for patients with ITN. Because of the higher risk of sensory morbidity and surgical risk as open surgery, RF is preferred as the recommended procedure for patients with ITN. (Source: Brazilian Journal of Otorhinolaryngology)

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Treatment of Meniere’s disease with Intratympanic Dexamethazone plus High Dosage of Betahistine

Conclusions Our preliminary results demonstrate that complete and substantial vertigo control is significantly higher in patients treated with a combination of HDBH and ITD. (Source: American Journal of Otolaryngology)

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Well: Think Like a Doctor: Thunder in the Head

Can you solve a real-life medical mystery involving a 59-year-old man tormented by a thunderous pounding in his head? (Source: NYT)

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Well: Think Like a Doctor: Thunder in the Head Solved

Readers try to solve the case of a middle aged man who developed chest pain that radiated to his neck, followed by a persistent and loud whooshing in his ear. (Source: NYT)

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The effectiveness of acupuncture as a treatment for tinnitus: a randomized controlled trial using 99m Tc-ECD SPECT

Conclusions ACP might reduce the effects of tinnitus on daily life; however, additional studies should be conducted to verify the effects of ACP on the neural architecture and brain function of tinnitus patients. Key Points • Efficacy of acupuncture on brain perfusion and symptoms of tinnitus patients. • Acupuncture improved the Tinnitus Handicap Inventory scores in tinnitus patients. • No significant changes in brain perfusion were observed after 12 twice-weekly sessions. • Perfusion changes would reflect changes in neuronal function. (Source: European Radiology)

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